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Foundayo vs Rybelsus

Compare Foundayo and Rybelsus on active ingredient, dosing schedule, FDA-approved use and pharmacy acquisition cost.

By Sam Reed · Founder and data leadVerified Aug 12, 2026

Foundayo

Eli Lilly

Active ingredient
Orforglipron
Form
FDA-approved for
Weight management
Not NADAC-indexed
lowest package, pharmacy acquisition cost

Rybelsus

Novo Nordisk

Active ingredient
Semaglutide
Form
TABLET
FDA-approved for
Type 2 diabetes
$995
lowest package, pharmacy acquisition cost

The short answer

Foundayo contains Orforglipron and Rybelsus contains Semaglutide. These are different molecules, so their dosing and clinical evidence differ.

Side by side

Costs are what a pharmacy pays to acquire each product, from CMS NADAC. Not a retail price, and not what you would pay.

Foundayo
Rybelsus
Lowest package cost
Not NADAC-indexed
$995
Active ingredient
Orforglipron
Semaglutide
Manufacturer
Eli Lilly
Novo Nordisk
Form
TABLET
FDA-approved for
Weight management
Type 2 diabetes
= better value on that rowScroll sideways on small screens — the first column stays pinned
Keep comparing
Data sources · cited with retrieval dates
  • CMS NADACNational Average Drug Acquisition Cost, weekly fileretrieved Aug 12, 2026
  • CMS Medicare Part DPrescriber public use file, by geography and drugretrieved Aug 12, 2026
  • CMS State Drug UtilizationQuarterly Medicaid prescription and reimbursement dataretrieved Aug 12, 2026

NADAC figures are pharmacy acquisition costs, not retail prices and not what you will pay. This content is educational and is not medical advice.