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SynergyRx vs TMates

SynergyRx and TMates compared on real monthly cost, medications, states served and how each one verifies.

By Sam Reed · Founder and data lead
TL;DR — our verdict
TMates rates higher at 7.8/10.
SynergyRx
5.6/10
$200per month, from
+$1/mo vs TMates
VerifiedVisit SynergyRx
TMates
7.8/10
$199per month, from
-$1/mo vs SynergyRx
VerifiedVisit TMates

Every line that matters

SynergyRx
TMates
Month-1 price
$200
$199
Month-2+ price
$200
$199
Three-month total
$600
$597
Membership fee
Not disclosed
Not disclosed
Consultation fee
None
None
Shipping
Free
Free
Medications
Compounded semaglutide, Ozempic, Wegovy, Compounded tirzepatide
Compounded semaglutide, Compounded tirzepatide
Forms
Injection
Injection
Medication type
Brand-name and compounded
Compounded only
States served
45 states
45 states
Insurance
No
Yes
Partner pharmacy
Not disclosed
Not disclosed
LegitScript badge
Not disclosed
Not disclosed
Cancel anytime
Yes
Yes
Our rating
5.6 / 10
7.8 / 10
Start today
Visit SynergyRx
Visit TMates
= better value on that rowScroll sideways on small screens — the first column stays pinned

Real cost over three months

An introductory month makes a programme look cheaper than it is. This is the first month plus two at the standing rate, which is where the two actually separate.

SynergyRx
Month 1
$200
Months 2–3
$200 × 2
Three-month total
$600
TMates
Month 1
$199
Months 2–3
$199 × 2
Three-month total
$597
Quick pick

Which one is you?

Choose SynergyRx if…
  • Users who want predictable bundled pricing with 24/7 support access
  • All-inclusive bundled pricing — no fees for messaging or adjustments
  • Free expedited shipping on all orders
  • 24/7 support access with unlimited messaging
Choose TMates if…
  • Users with insurance who want a coached GLP-1 program with multiple medication options
  • One of the few GLP-1 providers that accepts major insurance
  • Flat-rate pricing includes meds, consults, coaching, and delivery
  • 24/7 SMS-based coaching and digital check-ins
Safety

How both check out

SynergyRx
Verified

Partner pharmacy: Not published

LegitScript: No badge found · FDA letters: none on file

TMates
Verified

Partner pharmacy: Not published

LegitScript: No badge found · FDA letters: none on file

What the medication actually costs

Both programmes price their own service. This is what a pharmacy pays for the branded drug underneath, so you can see what each one adds on top.

Tirzepatide
$1,077
pharmacy acquisition cost, lowest package
Aug 12, 2026
Semaglutide
$992
pharmacy acquisition cost, lowest package
Aug 12, 2026
Semaglutide
$995
pharmacy acquisition cost, lowest package
Aug 12, 2026
Semaglutide
$871
pharmacy acquisition cost, lowest package
Aug 12, 2026
Tirzepatide
$1,052
pharmacy acquisition cost, lowest package
Aug 12, 2026

Source: CMS NADAC. This is what pharmacies pay, not a retail price and not what you would be charged.

Questions

Good to know

SynergyRx starts at $200 per month. $200/mo semaglutide, $299-347/mo tirzepatide. Consultation is included and shipping is free.

Data sources · cited with retrieval dates

NADAC figures are pharmacy acquisition costs, not retail prices and not what you will pay. This content is educational and is not medical advice.